How to click on Checkbox which is not intractable

I am trying to click on the Checkbox , but the element is not intractable through selenium(automation) as it is not visible in UI "as per SelectorsHub" . And there is no other option to click on Checkbox.

Below is the Code

<div class="expandingListItem" xpath="1"><div class="__react_component_tooltip t87682e2d-d3f9-492a-86e9-ff8647cfea93 place-bottom type-dark" id="21550Tooltip" data-id="tooltip">

   <a class="headerLabel"><div><input class="checkbox" type="checkbox" id="Main"><label for="Main"></label><span>Main </span></div><i class="material-icons"> expand_more</i></a><div class="contentWrapper "><div class="__react_component_tooltip t9d7a7973-4ccd-42c0-ad63-b3dfa99a9f29 place-bottom type-dark" id="nullTooltip" data-id="tooltip">

 </div><a class="contentChoice selected"><input class="checkbox" type="checkbox" id="3:21550:0" title=""><label for="3:21550:0"></label>Cint / Crowdology </a><div class="__react_component_tooltip tfbe137ad-b7b2-41a0-8c46-6fe81aba1c76 place-bottom type-dark" id="nullTooltip" data-id="tooltip">

</div><a class="contentChoice "><input class="checkbox" type="checkbox" id="50:21550:0" title=""><label for="50:21550:0"></label>Lucid </a><div class="__react_component_tooltip taab6a038-addb-4dc6-b569-10cd8bdba6c1 place-bottom type-dark" id="nullTooltip" data-id="tooltip">                                                                                                            

</div><a class="contentChoice "><input class="checkbox" type="checkbox" id="45:21550:0" title=""><label for="45:21550:0"></label>Pure Spectrum </a></div></div>

I am trying to Click in the checkbox